DERMAL ABSORPTION STUDIES
Study of absorption and/or metabolism processes after topical application onto the skin according international regulations:
- Using in vitro models such as Franz cells,
- Finite or infinite dose,
- Occlusive or non occlusive system
IN-VITRO METABOLISM
To determinate metabolic or enzymatic activity induced by a new active ingredient:
- Metabolism enzymatic identification,
- Induction/ inhibition studies,
- In vitro and in vivo metabolic profile,
- Microsomes and hepatocytes.
ANALYTICAL METHODS
To quantify accurately active ingredients or metabolites in all the substrates and compartments generated, the extraction procedures and analytical methods used are fully validated.
- Quantification of radiolabelled entities by liquid scintillation counting,
- Quantification of non radiolabelled entities by various chromatography techniques, mainly LC/MS-MS.